Evidence-Based Medicine Guidelines (EBMG) is a handbook on the wide range of diseases and conditions encountered by the physician in everyday practice. The guidelines have two approaches: problem-based and disease-specific, and are linked to the best available evidence including Cochrane Reviews and DARE abstracts. Other sources of evidence include clinical evidence, original articles and systematic reviews in clinical journals, abstracts in the Health Technology Assessment Database and the NHS Economic Evaluation Database, and clinical guidelines that describe evidence systematically. Where recommendations are given in the absence of high-quality evidence, they are based on textbooks, review articles, and expert opinion agreed upon by independent referees. Pulled together by hundreds of experts and compiled by the team of editors, EBMG also seeks to include guidelines where clinical evidence is incomplete or unavailable.
This book provides readers with a foundation of theoretical knowledge regarding patient safety as well as evidence-based strategies for preventing errors in various clinical settings. The authors; goal is to help clinicians and administrators gain the skills and knowledge they need to develop safe patient practices in their organizations.
Key topics include: An overview of evidence-based best practices for patient safety; clear explanation of important patient safety policies and legislation; innovative uses of technology such as computerized provider order entry, bar-coding medications, and computerized clinical decision support systems; and more.
The randmomized control clinical trial has become the gold standard in scientific method for the evaluation of pharmaceuticals, biologics, devices, procedures, and diagnostic tests. This trial design has been successfully used in both therapeutic and disease prevention trials. It is superior to alternative designs by eliminating several sources of bias which exist in those designs. This role has evolved over the past three decades in a number of disease areas including cardiology, opthalmology, cancer and AIDS. While the specifics in using the randomized control design for a specific intervention and disease may differ, the basic fundamentals still apply in developing the study protocol and operational procedures. These fundamentals include identifying the specific questions to be tested and appropriate outcome measures, detailing the intervention with visit schedules for subject evaluation, establishing an an interim data and safety monitoring plan, detailing the final analysis plan, and determining the organizational structure.